Promoting the health of livestock and poultry is essential for sustainable and productive farming systems. This special issue focuses on innovative strategies and scientific advances in nutrition, management, and disease prevention that contribute to healthy farming practices. Topics include the role of functional feeds, probiotics, and precision farming technologies in enhancing immune function, gut health, and overall resilience of animals. We also explore environmental and stress-related factors that influence animal health. By integrating research from nutrition, immunology, and veterinary science, this issue aims to provide holistic insights into improving animal health, productivity, and sustainability. We invite original research and comprehensive reviews that address current challenges and emerging solutions in the pursuit of healthier and more efficient livestock and poultry production.This Collection supports and amplifies research related toSDG 2, Zero Hunger,SDG 3, Good Health and Well-Being,SDG 6, Clean Water and Sanitation, andSDG 12, Responsible Consumption and Production.All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (detailshere). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visitOA funding and support, or emailOAfundingpolicy@springernature.comor the Editor-in-Chief. This Collection supports and amplifies research related toSDG 2, Zero Hunger,SDG 3, Good Health and Well-Being,SDG 6, Clean Water and Sanitation, andSDG 12, Responsible Consumption and Production.All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (detailshere). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visitOA funding and support, or emailOAfundingpolicy@springernature.comor the Editor-in-Chief. This Collection supports and amplifies research related toSDG 2, Zero Hunger,SDG 3, Good Health and Well-Being,SDG 6, Clean Water and Sanitation, andSDG 12, Responsible Consumption and Production. All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (detailshere). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visitOA funding and support, or emailOAfundingpolicy@springernature.comor the Editor-in-Chief. Submit your manuscript to this collection through the participating journal. Journal of Animal Science and Biotechnology is a leading open access journal publishing innovative research across agriculture, dairy and animal science.